Complete remission of advanced hepatocellular carcinoma by sorafenib: A case report

• 作者: Min Su Kim Young-Joo Jin Jin-Woo Lee Jung-il Lee Young soo Kim Sun young Lee Myoung Hun Chae
• 来源期刊: 世界胃肠肿瘤学杂志：英文版（电子版）
• 学科: 医学
• 关键词: HEPATOCELLULAR carcinoma SORAFENIB PORTAL VEIN THROMBOSIS Complete REMISSION
• 年，卷（期）: 2013,（2）
• 页码范围: 38-42
• 页数: 5页
• 分类号: R735.7

摘要

Hepatocellular carcinoma (HCC) is the fifth most common malignant disease worldwide, and curative treatment remains difficult because the majority of cases are diagnosed in the advanced stage. Sorafenib is the only known effective systemic treatment, but patients rarely achieve complete remission (CR). A 66-year-old man with a history of alcoholic liver cirrhosis with a diagnosis of advanced HCC, was initially treated with transarterial chemoembolization on four occasions. However, the disease progressed with portal vein thrombosis. Therefore, sorafenib was started, and 4 mo later, the patient achieved CR. The treatment was continued for 12 mo, and CR was maintained up to 4 mo after sorafenib discontinuation.