On Single Compartment Pharmacokinetic Model Systems that Obey Free Radical Copolymerization Kinetics and Multiplicity

• 作者: Kal Renganathan Sharma
• 来源期刊: 封装与吸附期刊(英文)
• 学科: 医学
• 关键词: SINGLE COMPARTMENT Pharmacokinetics Copolymer Composition Reactivity Ratios MULTIPLICITY State Space Model n MONOMERS
• 年，卷（期）: 2013,（3）
• 页码范围: 77-92
• 页数: 16页
• 分类号: R73

摘要

This study examines the issues in development of pharmacokinetic single compartment model for systems that obey free radical copolymerization kinetics. Copolymer composition as a function of reactivity ratios of comonomers for well mixed case was derived. For some cases, such as DEF-AN, diethyl fumarate and acrylonitrile system multiplicity in composition were found. The analysis is extended to n monomers. State space model expressions are used and the QSSA assumption is stated in state space equation form. Conditions when damped oscillations can be expected are noted. In addition to multiplicity in product composition, an account of reactivity ratios and other instances of multi- plicity were found during the pharmacodynamics of the free radical polymerization reactions. A careful study of initiated case, thermal case, 1 CSTR and 2 CSTRS was undertaken and results were presented. Numerical integration techniques were employed on the desktop computer. Steady state and transient state conversion for initiated case and thermal case for 1 CSTR and 2 CSTRs were calculated and plotted in Figures 7-9 and 12. No multiplicity was found in the thermal case for 1 CSTR in the dynamics of transient monomer conversion. Multiplicity was found in the initiated case for 1 CSTR in the dynamics of transient conversion of monomer. The multiplicity was found in the second CSTR for the case of 2 CSTRs in series. No multiplicity was found in the case of initiator decay.