类型的表情我在畿尼猪与的巩膜的骨胶原， 2 integrin 和 1 integrin 散焦近视和近视的形成上的 bFGF 的禁止的效果

• 作者: Chun-Lei Fan Gui-Bo Liu Li-Hui Zhan Su-Fen Guo Xiao-Dan Tian Yan-Chun Xu Yong-Xia Cheng
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: DEFOCUS MYOPIA type Ⅰ collagen α2 INTEGRIN β1 INTEGRIN BFGF
• 年，卷（期）: 2013,（1）
• 页码范围: 54-58
• 页数: 5页
• 分类号: R778.11

摘要

AIM:To investigate the expressions of type I collagen, α2 integrin and β1 integrin in the posterior sclera of guinea pigs with defocus myopia and whether basic fibroblast growth factor (bFGF) injection inhibits the formation and development of myopia by upregulating the expression of type I collagen, α2 integrin and β1 integrin. METHODS:After 14 days of treatment, the refractive state and axial length were measured and the levels of type I collagen, α2 integrin and β1 integrin were assayed in the posterior sclerae of groups of guinea pigs that wore a monocular-7D polymethylmethacrylate (PMMA) lens or had -7D lens wear followed by the peribulbar injection of Phosphate Buffer Solution (PBS) or bFGF. The untreated fellow eye served as a control. Guinea pigs with no treatment served as normal group. ·RESULTS:The results showed that 14 days of monocular defocus increased axial eye length and refraction, while bFGF delivery inhibited them markedly. Further, it was also found that the monocular-7D lens could decrease the levels of type I collagen, α2 integrin and β1 integrin expressions, while, unlike PBS, bFGF increased them significantly in comparison to contralateral control eyes and normal eyes. CONCLUSION:bFGF can prevent the formation anddevelopment of defocus myopia by upregulating the expressions of type I collagen, α2 integrin and β1 integrin. Taken together, our results demonstrate that bFGF promotes sclera remodeling to prevent myopia in guinea pigs.