The CXXC-TET bridge-mind the methylation gap!

• 作者: Donncha S Dunican Richard R Meehan Sari Pennings
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2013,（8）
• 所属期刊栏目: RESEARCH HIGHLIGHTS
• 页码范围: 973-974
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/cr.2013.71

摘要

CG-rich DNA "reader" proteins that bind non-methylated CpG sequences have emerged as critical factors to the process of cell differentiation and development.In a recent paper in Nature,Ko et al.show that the CXXC domain protein,IDAX,plays a crucial role as a CG-rich DNA-binding factor in the regulation of Ten-Eleven-Translocation 2 (TET2) protein function. Epigenetic processes are defined by transmissible alterations in gene expression,which are independent of any change in DNA sequence [1].A feature of mammalian genomes is the presence of modified cytosines at CpG dinucleotides,the bulk of which are methylated as 5-methylcytosine (5mC).Short stretches (1-2 kb long) of CpG-rich unmethylated DNA stand out as CpG islands (CGIs) [1,2].