在在亚洲人口的 lumican 基因 -1554 T/C 多型性和高近视之间的协会: 元分析

• 作者: Chang-Jun Lan Long-Qian Liu Meng Liao Xu-Bo Yang Xuan Liao
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: LUMICAN high MYOPIA gene POLYMORPHISM META-ANALYSIS
• 年，卷（期）: 2013,（5）
• 页码范围: 696-701
• 页数: 6页
• 分类号: R778.11

摘要

AIM:To investigate the association between lumican gene-1554 T/C polymorphism and high myopia susceptibility.METHODS:We searched the published literature in the Medline,Embase,and CBM databases from inception to July 2013.A meta-analysis was performed by the programs RevMan 5.1 and Stata 12.0,and the odds ratio(OR) with 95% confidence interval(CI) was calculated in fixed or random effect model based on heterogeneity test among studies.RESLUTS:Seven case-control studies with a total of 1 233 cases and 936 controls were included.A statistical significant association with high myopia was observed in the recessive model(TT vs CT +CC:OR=1.92;95% CI=1.14-3.23) and codominant model(TT vs CT:OR=1.81,95%CI=1.19-2.75).CONCLUSION:The present meta-analysis suggested that lumican-1554 T/C polymorphism might be moderately associated with high myopia susceptibility.This conclusion warrants confirmation by further studies.