The Polymorphism and Transformation of (3aRS, 4RS, 7RS, 7aSR)-2-(Tricyclo[3.3.1.13,7]decan-1-yl)-4,5,6,7-tetrahydro-4,7-eposyisoindoline-1,3-dione (SU2162)—A Novel Anticancer Compound

• 作者: Chunmei Tong Hui Yang Lin Luo Ruiling Liu Tingyu Huang Wenfei Chen Yuqing Huang Zaiyou Tan
• 来源期刊: 结晶过程及技术期刊(英文)
• 学科: 化学
• 关键词: SU2162 POLYMORPHISM Crystal Form MELTING METHOD SOLVENT METHOD
• 年，卷（期）: 2014,（1）
• 页码范围: 27-30
• 页数: 4页
• 分类号: O6

摘要

Objective: To determine the transformation between two known crystal forms of the title compound (C18H23NO3, Mr = 301.37). Methods: To recrystallize or heat the crystals and determine the crystal form by testing the melting points. Results: Both the two known crystal forms of the title compound can be changed by dissolving into different organic solvents such as acetone and ethyl acetate. Crystal form I was not influenced by heating while crystal form II can be transformed to crystal form I through melting method. Conclusion: Organic solvents have significant influences on the two crystal forms of title compound. Crystal form I shows a better thermal stability than crystal form II.