Predicting residue contacts for protein-protein interactions by integration of multiple information

• 作者: Duc Luu Ngo Kenji Satou Lan Anh T. Nguyen Mamoru Kubo Osamu Hirose Thammakorn Saethang Tu Kien T. Le Vu Anh Tran Xuan Tho Dang Yoichi Yamada
• 来源期刊: 生物医学工程(英文)
• 学科: 医学
• 关键词: Residue-Residue CONTACTS Domain-Domain INTERACTIONS PROTEIN-PROTEIN INTERACTIONS DOMAIN Interfaces RESIDUE Co-Evolution Contact Potentials
• 年，卷（期）: swyxgcyw_2014,（1）
• 页码范围: 28-37
• 页数: 10页
• 分类号: R73

摘要

Detailed knowledge of interfacial region between interacting proteins is not only helpful in annotating function for proteins, but also very important for structure-based drug design and disease treatment. However, this is one of the most difficult tasks and current methods are constrained by some factors. In this study, we developed a new method to predict residue-residue contacts of two interacting protein domains by integrating information about evolutionary couplings andamino acid pairwise contact potentials, as well as domain-domain interaction interfaces. The experimental results showed that our proposed method outperformed the previous method with the same datasets. Moreover, the method promises an improvement in the source of template-based protein docking.