Fetal stem cell transplantation: Past, present, and future

• 作者: Tetsuya Ishii Koji Eto
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: FETAL tissue FETAL STEM CELLS Fetus Embryonic STEM CELLS Transplantation Clinical trials
• 年，卷（期）: 2014,（4）
• 页码范围: 404-420
• 页数: 17页
• 分类号: R457.7

摘要

Since 1928, human fetal tissues and stem cells have been used worldwide to treat various conditions. Although the transplantation of the fetal midbrain substantia nigra and dopaminergic neurons in patients suffering from Parkinson’s disease is particularly noteworthy, the history of other types of grafts, such as those of the fetal liver, thymus, and pancreas, should be addressed as there are many lessons to be learnt for future stem cell transplantation. This report describes previous practices and complications that led to current clinical trials of isolated fetal stem cells and embryonic stem(ES) cells. Moreover, strategies for transplantation are considered, with a particular focus on donor cells, cell processing, and the therapeutic cell niche, in addition to ethical issues associated with fetal origin. With the advent of autologous induced pluripotent stem cells and ES cells, clinical dependence on fetal transplantation is expected to gradually decline due to lasting ethical controversies, despite landmark achievements.