Human induced pluripotent stem cells: A new source for brown and white adipocytes

• 作者: Anne-Laure Hafner Christian Dani
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: Human induced pluripotent STEM CELLS Mesenchymal STEM CELLS BROWN ADIPOCYTES WHITE ADIPOCYTES Obesity LIPODYSTROPHY
• 年，卷（期）: 2014,（4）
• 页码范围: 467-472
• 页数: 6页
• 分类号: R329.2

摘要

Mesenchymal stem cells(MSCs) derived from human induced pluripotent stem cells(hiPSCs) provide a novel source for generating adipocytes, thus opening new avenues for fundamental research and clinical medicine. We present the adipogenic potential of hiPSCs and the various methods to derive hiPSC-MSCs. We discuss the main characteristic of hiPSC-MSCs, which is their low adipogenic capacity as compared to adult-MSCs. Finally, we propose several hypotheses to explanation this feature, underlying a potential critical role of the micro-environment. We favour the hypothesis that the range of factors or culture conditions required to induce adipocyte differentiation of MSCs derived from adult tissues and from embryonic-like cells could differ.