Recent developments in optimal experimental designs for functional magnetic resonance imaging

• 作者: M'hamed Temkit Ming-Hung Kao Weng Kee Wong
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: A-OPTIMALITY Blocked designs Design EFFICIENCIES D-OPTIMALITY Genetic algorithms HADAMARD sequences M-SEQUENCES
• 年，卷（期）: 2014,（7）
• 页码范围: 437-445
• 页数: 9页
• 分类号: R445.2

摘要

Functional magnetic resonance imaging(fMRI)is one of the leading brain mapping technologies for studying brain activity in response to mental stimuli.For neuroimaging studies utilizing this pioneering technology,there is a great demand of high-quality experimental designs that help to collect informative data to make precise and valid inference about brain functions.This paper provides a survey on recent developments in experimental designs for fMRI studies.We briefly introduce some analytical and computational tools for obtaining good designs based on a specified design selection criterion.Research results about some commonly considered designs such as blocked designs,and m-sequences are also discussed.Moreover,we present a recently proposed new type of fMRI designs that can be constructed using a certain type of Hadamard matrices.Under certain assumptions,these designs can be shown to be statistically optimal.Some future research directions in design of fMRI experiments are also discussed.