3-51 Genistein Combined with X-ray Radiation Induces Oxidative Stress and Oxidative Damage in A549 Cells but Not in MRC-5 Cells

• 作者: Jin Xiaodong Li Ping Li Qiang Liu Bingtao Liu Xiongxiong
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报：英文版
• 学科: 物理学
• 关键词: GENISTEIN COMBINED RADIATION
• 年，卷（期）: 2014,（1）
• 页码范围: 145-146
• 页数: 2页
• 分类号: O4

摘要

Selectively killing cancer without harming normal tissue is a fundamental challenge in cancer therapy. Elevatedoxidative stress and aberrant redox homeostasis are frequently observed in cancer cells compared with their normalcell counterparts[1]. A small shift toward an oxidizing condition in cells may lead to elevated proliferation andinduction of adaptive response. However, a high oxidizing condition often results in cell injury and cell death.Persistent high level of reactive oxygen species (ROS) in cancer cells usually elicits increased cell proliferation andadaptive responses that may contribute to tumorigenesis, metastasis, and treatment resistance. However, normalcells may still maintain redox homeostasis through adaptive responses. Therefore, regulating intracellular redoxstate may represent an ideal strategy to selectively sensitize cancer cells to oxidative stress-inducing therapy, suchas radiotherapy.