3-56 Curcumin Ameliorates Heavy Ion Irradiation-induced Learning and Memory De cits Through Enhancing Nrf2 Antioxidant Signaling Pathways

• 作者: Li Hongyan Liu Yang Xie Yi Zhang Hong Zhao Qiuyue Zhou Xin
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报：英文版
• 学科: 物理学
• 关键词: CURCUMIN Ameliorates HEAVY
• 年，卷（期）: 2014,（1）
• 页码范围: 150-151
• 页数: 2页
• 分类号: O4

摘要

Oxidative stress is one of the major mechanisms implicated in carbon ion irradiation[1;2]. Curcumin is a naturalphenolic compound with impressive antioxidant properties[3]. What's more, curcumin is recently proved to exertradioprotective effect. In vivo, we investigated the protective effects of curcumin against 12C6+radiation-inducedcerebral injury.Our results showed that 4 Gy heavy ion radiation-induced spatial strategy and memory decline (Fig. 1), reductionof brain Superoxide Dismutase (SOD) activity levels, were all consistently improved by curcumin, as well as theaugmentation of cerebral malonaldehyde (MDA), was lowered by curcumin (Fig. 2). Furthermore, both the cerebralcells Nuclear erythroid 2-related factor 2 (Nrf2) protein and three typically recognized Nrf2 downstream genes,NADP(H) quinine oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), and -glutamyl cysteine synthetase (-GCS) were consistently up-regulated in curcumin-pretreated mice (Fig. 3).