Mechanical circulatory support in lung transplantation:Cardiopulmonary bypass,extracorporeal life support,and ex-vivo lung perfusion

• 作者: Amy Pope-Harman Bryan A Whitson Curtis A Dumond Don Hayes Jr Eliza W Beal Jim Ralston Shaylyn C Bennett Sylvester Black Thomas Preston
• 来源期刊: 世界呼吸病学杂志
• 学科: 医学
• 关键词: LUNG transplant CARDIOPULMONARY bypass EXTRACORPOREAL membrane OXYGENATION EXTRACORPOREAL life support EXTRACORPOREAL LUNG assist Interventional LUNG assist EX-VIVO LUNG perfusion
• 年，卷（期）: sjhxbxzz,（2）
• 页码范围: 78-92
• 页数: 15页
• 分类号: R

摘要

Lung transplant is the standard of care for patients with end-stage lung disease refractory to medical management.There is currently a critical organ shortage for lung transplantation with only 17%of offered organs being transplanted.Of those patients receiving a lung transplant,up to 25%will develop primary graft dysfunction,which is associated with an 8-fold increase in 30-d mortality.There are numerous mechanical lung assistance modalities that may be employed to help combat these challenges.We will discuss the use of mechanical lung assistance during lung transplantation,as a bridge to transplant,as a treatment for primary graft dysfunction,and finally as a means to remodel and evaluate organs deemed unsuitable for transplant,thus increasing the donor pool,improving survival to transplant,and improving overall patient survival.