Mesenchymal stem cells in the treatment of inflammatoryand autoimmune diseases in experimental animal models

• 作者: Matthew W Klinker Cheng-Hong Wei
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: MESENCHYMAL STROMAL CELLS Mesenchymalstem CELLS AUTOIMMUNITY ANIMAL models Inflammation IMMUNOTHERAPY
• 年，卷（期）: 2015,（3）
• 页码范围: 556-567
• 页数: 12页
• 分类号: R

摘要

Multipotent mesenchymal stromal cells [also known asmesenchymal stem cells （MSCs）] are currently beingstudied as a cell-based treatment for inflammatorydisorders. Experimental animal models of humanimmune-mediated diseases have been instrumental inestablishing their immunosuppressive properties. Inthis review, we summarize recent studies examiningthe effectiveness of MSCs as immunotherapy in severalwidely-studied animal models, including type 1 diabetes,experimental autoimmune arthritis, experimentalautoimmune encephalomyelitis, inflammatory boweldisease, graft-vs -host disease, and systemic lupuserythematosus. In addition, we discuss mechanismsidentified by which MSCs mediate immune suppressionin specific disease models, and potential sources offunctional variability of MSCs between studies.