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摘要:
All organisms must transmit genetic information to offspring through cell division, and mitotic spindle participates in the process. Spindle dynamics through depolymerization or polymerization of microtubules generates the driving force required for chromosome movements in mitosis. To date, studies have shown that microtubule arrays control the directions of cell division and diverse microtubule-associated proteins regulate cell division. But a clear picture of how microtubules and microtubule-associated proteins modulate cell division remains unknown. Depletion of end-binding protein 1 by RNA-mediated inhibition shows that one of the microtubule-associated proteins, end-binding protein 1, plays a crucial role in mitotic spindle formation and promotes microtubule dynamics and is needed for the proper segregation of mitotic chromosomes during anaphase in Drosophila cells. Here, we review the properties of end-binding protein 1 and the roles of end-binding protein 1 in regulating microtubule behavior and in cell cycle.
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篇名 The Evolution of Microtubule End-Binding Protein 1 (EB1) and Roles in Regulating Microtubule Behavior
来源期刊 美国植物学期刊(英文) 学科 医学
关键词 MICROTUBULES End-Binding Protein 1 CHROMOSOME SEGREGATION
年,卷(期) 2015,(13) 所属期刊栏目
研究方向 页码范围 2114-2121
页数 8页 分类号 R73
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研究主题发展历程
节点文献
MICROTUBULES
End-Binding
Protein
1
CHROMOSOME
SEGREGATION
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期刊影响力
美国植物学期刊(英文)
月刊
2158-2742
武汉市江夏区汤逊湖北路38号光谷总部空间
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1814
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0
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