Effects of carob-bean gum thickened formulas on infants’reflux and tolerance indices

• 作者: Anne Schaafsma Elena Dimitrova Miglena Georgieva Niya Rasheva Ruzha Pancheva Yannis Manios
• 来源期刊: 世界临床儿科杂志
• 学科: 医学
• 关键词: REFLUX CAROB BEAN gum Galactomannans INFANTS Formula
• 年，卷（期）: 2016,（1）
• 页码范围: 118-127
• 页数: 10页
• 分类号: R392-33

摘要

AIM:To examine the effect of carob-bean gum(CBG)thickened-formulas on reflux and tolerance indices in infants with gastro-esophageal reflux(GER).METHODS:Fifty-six eligible infants(1-6 mo old)were randomly allocated to receive for two weeks a formula with either 0.33 g/100 mL(Formula A)or 0.45 g/100 mL(Formula B)of cold soluble CBG galactomannans respectively,or a formula with 0.45 g/100 mL of hot soluble CBG galactomannans(Formula C).No control group receiving standard formula was included in the study.Data on the following indices were obtained both at baseline and follow-up from all study participants:24 h esophageal pH monitoring indices,anthropometrical indices(i.e.,body weight and length)and tolerance indices(i.e.,frequency of colics;type and frequency of defecations).From the eligible infants,forty seven were included in an intention-to-treat analysis to examine the effects of the two-week trial on esophageal 24 h pH monitoring,growth and tolerance indices.Repeated Measures ANOVA was used to examine the research hypothesis.RESULTS:Regarding changes in 24 h pH monitoring indices,significant decreases from baseline to followup were observed in the“Boix Ochoa Score”(i.e.,an index of esophageal acid exposure),in the total number of visible refluxes and in all symptoms related indices due to acid reflux only for infants provided with Formula A,while no significant changes were observed for infants provided with Formulas B and C.In addition,the significant decreases observed in two symptoms related pH monitoring indices(i.e.,“Symptom index for reflux”and“Percentage of all reflux”)for infants provided with Formula A were also found to differentiate significantly compared to the changes observed in the other two groups(P=0.048 and P=0.014 respectively).Concerning changes in anthropometric indices,body weight significantly increased among infants provided with Formulas A and C,but not for infants provided with Formula B.As far as tolerance indices were concerned,the numbers of total and diarrheic defecat