Reprogramming of germ cells into pluripotency

• 作者: Yoichi Sekita Toshinobu Nakamura Tohru Kimura
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: Primordial GERM CELL EMBRYONIC GERM CELL GERM CELL tumor REPROGRAMMING Induced PLURIPOTENT stem CELL Small molecule compound Gene Signal Transcription factor
• 年，卷（期）: 2016,（8）
• 页码范围: 251-259
• 页数: 9页
• 分类号: R

摘要

Primordial germ cells (PGCs) are precursors of all gametes, and represent the founder cells of the germline. Although developmental potency is restricted to germ-lineage cells, PGCs can be reprogrammed into a pluripotent state. Specifically, PGCs give rise to germ cell tumors, such as testicular teratomas, in vivo , and to pluripotent stem cells known as embryonic germ cells in vitro . In this review, we highlight the current knowledge on signaling pathways, transcriptional controls, and post-transcriptional controls that govern germ cell differentiation and de-differentiation. These regulatory processes are common in the reprogramming of germ cells and somatic cells, and play a role in the pathogenesis of human germ cell tumors.