Bleeding risk with clopidogrel and percutaneous endoscopic gastrostomy

• 作者: Amin O Mahdi Chela Harleen Douglas L Nguyen Matthew L Bechtold Murtaza Arif Umair Sohail
• 来源期刊: 世界胃肠内镜杂志：英文版（电子版）
• 学科: 医学
• 关键词: PERCUTANEOUS endoscopic GASTROSTOMY CLOPIDOGREL BLEEDING COMPLICATIONS ANTIPLATELETS
• 年，卷（期）: 2016,（16）
• 页码范围: 553-557
• 页数: 5页
• 分类号: R

摘要

AIM To compare bleeding within 48 h in patients undergoing percutaneous endoscopic gastrostomy (PEG) with or without clopidogrel.METHODS After institutional review board approval, a retrospectivestudy involving a single center was conducted on adult patients having PEG (1/08-1/14). Patients were divided into two groups: Clopidogrel group consisting of those patients taking clopidogrel within 5 d of PEG and the non-clopidogrel group including those patients not taking clopidogrel within 5 d of the PEG.RESULTS Three hundred and nineteen PEG patients were found.One hundred and sixty-eight males and 151 females with mean body mass index 28.47 ± 9.75 kg/m2 and mean age 65.03 ± 16.11 years were identified. Thirtythree patients were on clopidogrel prior to PEG with 286 patients not on clopidogrel. No patients in either group developed hematochezia, melena, or hematemesis within 48 h of percutaneous endoscopic gastrostomy(PEG). No statistical differences were observed betweenthe two groups with 48 h for hemoglobin decrease of >2 g/dL (2 vs 5 patients; P = 0.16), blood transfusions(2 vs 7 patients; P = 0.24), and repeat endoscopy for possible gastrointestinal bleeding (no patients in either group).CONCLUSION Based on the results, no significant post-procedure bleeding was observed in patients undergoing PEG with recent use of clopidogrel.