4-57 Increase in Expression of Indoleamine 2,3-dioxygenase in Iron-ion Irradiation-induced Bone Marrow Dendritic Cells Damage in Mice

• 作者: Xie Yi Zhang Hong
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报：英文版
• 学科: 物理学
• 年，卷（期）: 2016,（1）
• 页码范围: 183-183
• 页数: 1页
• 分类号: O4

摘要

High linear energy transfer radiation is known to deposit higher energy in tissues and cause greater damage than low-LET irradiation[1].Local immunosuppression is frequently observed after irradiation(IR).Dendritic cells(DCs)play important roles in the initiation and maintenance of the immune response[2].The dysfunction of DCs contributes to tumor evasion and growth.However,molecular mechanisms underlying the establishment of immune tolerance induced by heavy ion IR through this DC population are poorly understood.