4-64 Selective ATP Hydrolysis Inhibition in F1Fo ATP Synthase Enhances Radiosensitivity of Non-small-cell Lung Cancer Cells(A549)

• 作者: Di Cuixia Gan Lu Si Jing Sun Chao Wang Yupei Zhang Hong Zhou Rong
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报：英文版
• 学科: 物理学
• 年，卷（期）: 2016,（1）
• 页码范围: 190-191
• 页数: 2页
• 分类号: O4

摘要

F1Fo ATP synthase,or named ATPase(EC 3.6.1.3)(referred as the same enzyme hereafter)catalyzes the phosphorylation of ADP to ATP by exploiting a the transmembrane proton motive force(Δp)produced by the oxidation of nutrient substrates in mitochondrial respiration in all organisms.However,under peculiar physiological conditions when mitochondrial respiration is impaired which lead to the electrochemical gradient across the inner membrane collapse,the F1Fo ATP synthase switches its catalytic activity from ATP synthesis to ATP hydrolysis for maintaining theΔp.