Voxel Placement Precision for GABA-Edited Magnetic Resonance Spectroscopy

• 作者: Ashley D. Harris Guangbin Wang Michael Sch?r Nicolaas A. J. Puts Peter B. Barker Richard A. E. Edden Tao Gong Xue Bai
• 来源期刊: 放射学期刊(英文)
• 学科: 医学
• 关键词: MRS VOXEL PLACEMENT PRECISION VOXEL PRESCRIPTION REGISTRATION
• 年，卷（期）: 2017,（1）
• 页码范围: 35-44
• 页数: 10页
• 分类号: R73

摘要

The purpose of the present study was to assess the reproducibility of voxel placement for GABA-edited MRS. GABA-edited MRS data were acquired in 13 healthy volunteers from (3 cm)3 voxel;and within the same session a second acquisition was independently prescribed. A three-dimensional voxel mask image was reconstructed in T1-image-space using the SVMask tool (in house software). Reproducibility of voxel placement was assessed using the Dice overlap coefficient, both within-subject and between-subject following co-registration of T1 images and transformation of voxel mask images to standard space. Within-subject overlap coefficients were 86% ± 5%. Between-subject overlap coefficients were 75% ± 10%. For the two voxel locations considered (occipital and sensorimotor), voxel overlap was very similar. Between-subject values are higher due to between-session effects, anatomical variability and volume mismatch in standard space. While surprisingly low in terms of volume overlap, the overlap coefficients correspond to acceptable linear displacements.