Introduction: This work aims to identify and analyze the anxio-depressive morbidity that the renal insufficiency in hemodialysis can present. Methodology: The framework of this work was the department of nephrology and the hemodialysis unit of the CHU Sylvanus Olympio of Lome. This was a cross-sectional, single-pass, descriptive and analytical study that ran from January 1st, 2016 to June 30th, 2016. Included were all chronic hemodialysis patients who gave their free and well-informed consent and who have no psychiatric history. To assess anxiety and depression, the Hospital Anxiety and Depressive Scale of Zigmond and Snaith was used. The processing of the data was done with the software Epi Info 7 (version 7.1.2.0). Results: The number of patients was 91 and all were included. The mean age at 46.51 ± 14.41 years with extremes of 11 and 84 years and a sex ratio at 1.6 were observed. Anxiety (A3) was in 52.8% of women and depressed (D3) in 63.2% of men. The absence of social security increases the risk of anxiety disorders among respondents by three (RR = 2.6, p = 0.04). A duration of change of Chronic Renal Failure (CRF) less than 6 months was associated with the occurrence of depression (p = 0.04) with hemodialysis patients. The relative risk of depressive episodes increased three-fold with the hemodialysis patients (RR = 2.7). Conclusion: Collaboration between psychiatrists, psychologists and somaticians (doctors of the body) can occur at different times during dialysis, in order to overcome the difficulties that may arise during the treatment.