Synthesis, Molecular Structure and Antibacterial Activity of Benzylmethyl-4-Methyl-3-Thiosemicarbazone

• 作者: Elvis N. Eyonganyoh Emmanuel N. Nfor Godfred A. Ayimele James A. Mbah
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Benzylmethyl-4-Methyl-3-Thiosemicarbazone ANTIBACTERIAL ACTIVITY CRYSTAL Structure
• 年，卷（期）: 2017,（2）
• 页码范围: 83-90
• 页数: 8页
• 分类号: O6

摘要

A novel Schiff base, benzylmethyl-4-methyl-3-thiosemicarbazone (BMM) de-rived from benzylmethylketone and 4-methylthiosemicarbazide was synthe-sized and characterized by elemental analysis, spectroscopic methods (IR, 1H NMR, 13C NMR) and physical means. The single crystal structure analysis of the Schiff base reveals that it crystallizes in a monoclinic system in the P21/c space group. BMM revealed moderate antibacterial activity on three bacterial strains with diameter zone of inhibition of 16 mm (E. coli), 14 mm (K. pneumonia) and 13 mm (S. epider-midis) compared with the standard drug, ciprofloxacin.