The Expression of PI3K, AKT, β-Catenin and VEGFR2 in Medulloblastoma

• 作者: Xiao Lin Yu Li
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: PI3K AKT Β-CATENIN VEGFR2 MEDULLOBLASTOMA
• 年，卷（期）: 2017,（3）
• 页码范围: 32-38
• 页数: 7页
• 分类号: R73

摘要

Medulloblastoma (MB) is common tumor of the central nervous system in children. It’s reported that PI3K/AKT and Wnt signal pathway have important roles in MB. This study aims to investigate the expression of PI3K, AKT, Β-catenin and VEGFR-2 in MB to find a new pathway for MB. A total of 33 MB and 17 control brain cases were retrospectively evaluate d for PI3K, AKT, β-catenin and VEGFR-2 expression by immunohistochemical staining, and the relationship with clinical feature were analyzed. The positive rate of PI3K, AKT, β-catenin and VEGFR-2 in 33 MB were significantly greater than those in control group (P