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摘要:
Advanced biophysical wound healing therapies can apply mechanical, electrical, or light energy to re-stimulate healing processes in chronic wounds. Despite the growing evidence of the clinical efficacy of these therapies, the optimal treatment stimulation parameters remain unknown and there are no standard treatment protocols. We introduce a closed-loop control design as an experimental system to study the dose-response of wound healing therapy treatment within a prescribed multidimensional and multimodal stimulation parameter space. Systems engineering approaches are applied to the control problem for estimation of a transfer function and model equations derived for use in optimal model-based control. The experimental control system design consisted of simultaneous application of biophysical energies inputted into a wound system. A study design set up including the use of negative pressure wound therapy, electrical stimulation therapy, and photobiomodulation device systems was described. Treatment stimulation parameters were selected from experimental ranges used in the scientific literature. Classical control methods and model-based control were suggested for model selection and evaluation and design of the overall control system. An experimental design for multimodal biophysical wound healing therapy control system is introduced to establish the dose-response interactions for development of therapeutic applications and device design.
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篇名 A Control System Design to Establish Dose-Response Relationships in Wound Healing Therapy
来源期刊 生物医学工程(英文) 学科 医学
关键词 Chronic WOUNDS High voltage pulsed current Low level light THERAPY Negative pressure WOUND THERAPY Modeling and control PHOTOBIOMODULATION WOUND HEALING
年,卷(期) 2017,(5) 所属期刊栏目
研究方向 页码范围 76-85
页数 10页 分类号 R73
字数 语种
DOI
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研究主题发展历程
节点文献
Chronic
WOUNDS
High
voltage
pulsed
current
Low
level
light
THERAPY
Negative
pressure
WOUND
THERAPY
Modeling
and
control
PHOTOBIOMODULATION
WOUND
HEALING
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
生物医学工程(英文)
月刊
1937-6871
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
252
总下载数(次)
1
总被引数(次)
0
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