Russell body gastritis with Dutcher bodies evaluated using magnification endoscopy

• 作者: Akinobu Ohno Hiroaki Kataoka Kenji Yorita Koji Kojima Kunihisa Uchita Naoto Kuroda Shinichi Iwamura Takehiro Iwasaki Yutaka Tsutsumi
• 来源期刊: 世界胃肠内镜杂志：英文版（电子版）
• 学科: 医学
• 关键词: 卢梭身体胃炎 莫特房间 更荷兰的身体 联系 Mucosa 的淋巴的织物淋巴瘤 PLASMACYTOMA 有狭窄乐队的成像的放大内视镜检查法
• 年，卷（期）: 2017,（8）
• 页码范围: 417-424
• 页数: 8页
• 分类号: R573

摘要

Russell body gastritis(RBG) is an unusual type of chronic gastritis characterized by marked infiltration of Mott cells,which are plasma cells filled with spherical eosinophilic bodies referred to as Russell bodies.It was initially thought that Helicobacter pylori(H.pylori) infection was a major cause of RBG and that the infiltrating Mott cells were polyphenotypic;however,a number of cases of RBG without H.pylori infection or with monoclonal Mott cells have been reported.Thus,diagnostic difficulty exists in distinguishing RBG with monoclonal Mott cells from malignant lymphoma.Here,we report an unusual case of an 86-year-old-Japanese man with H.pylori-positive RBG.During the examination of melena,endoscopic evaluation confirmed a 13-mm whitish,flat lesion in the gastric antrum.Magnification endoscopy with narrowband imaging suggested that the lesion was most likely a poorly differentiated adenocarcinoma.Biopsy findings were consistent with chronic gastritis with many Mott cells with intranuclear inclusions referred to as Dutcher bodies.Endoscopic submucosal dissection confirmed the diagnosis of RBG with kappa-restricted monoclonal Mott cells.Malignant lymphoma was unlikely given the paucity of cytological atypia and Ki-67 immunoreactivity of monoclonal Mott cells.This is the first reported case of RBG with endoscopic diagnosis of malignant tumor and the presence of Dutcher bodies.