Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity

• 来源期刊: 药学学报（英文版）
• 关键词: Cruciferae Isatis indigotica Indole alkaloid sulfonic acids Isatibis indosulfonic acids Isatindosulfonic acids Antiviral activity
• 年，卷（期）: 2017,（3）
• 页码范围: 334-341
• 页数: 8页
• 语种: 英文

摘要

Six new indole alkaloid sulfonic acids (1-6),together with two analogues (7 and 8) that were previously reported as synthetic products,were isolated from an aqueous extract of the Isatis indigotica root.Their structures including the absolute configurations were determined by spectroscopic data analysis,combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra.In the preliminary assay,compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza vims A/Hanfang/359/95 (H3N2),respectively.