Visualization of 3-Dimensional Vectors in a Dynamic Embryonic System—WormGUIDES

• 作者: Anthony Santella Dali Wang Eric Wang Zhirong Bao Zi Wang
• 来源期刊: 电脑和通信(英文)
• 学科: 医学
• 关键词: EMBRYONIC Data VISUALIZATION WormGUIDES WORKFLOW Software Architecture DIVISION Orientation Cell Polarity C. ELEGANS
• 年，卷（期）: dnhtxyw_2017,（12）
• 页码范围: 70-79
• 页数: 10页
• 分类号: R73

摘要

WormGUIDES is an open-source dynamic embryonic system designed to facilitate global understanding of cellular decisions in the developing nervous system of the nematode C. elegans. WormGUIDES was designed to allow investigation and exploration of the observational results of the C. elegans life cycle from laboratory experiments. In the process of a mechanistic C. elegans model development, some functionalities of WormGUIDES needed to be enhanced to support model validation and verification. In this study, a new way to visualize 3-dimentional vectors within WormGUIDES was investigated and presented. Then, the practical values of this method were demonstrated by visualizing two biologically significant directions (i.e., division orientation and cell polarity) of individual embryonic cells in C. elegans. Lastly, a mathematic approach was designed to illustrate the differences between these two sets of vectors and provide easy indications of the location of these individual cells that have large data discrepancies within the C. elegans embryonic system.