Biocompatibility and Antibacterial Effects of 6-Deoxy-6-Aminoethyleneamino Cellulose

• 作者: Cornelia Wiegand Michael Zieger Peter Elsner Susanne Finger Thomas Heinze Tim Liebert Uta-Christina Hipler
• 来源期刊: 生物科学与医学(英文)
• 学科: 化学
• 关键词: 6-Deoxy-6-Aminoethyleneamino Celluloses ANTIBACTERIAL BACTERIA BIOCOMPATIBILITY BIOMACROMOLECULE KERATINOCYTE
• 年，卷（期）: 2018,（1）
• 页码范围: 51-62
• 页数: 12页
• 分类号: O6

摘要

Recently, there is a need of alternatives to antibiotics due to increasing antibiotic-resistant microorganism. Promising classes of bioactive polymers are 6-deoxy-6-amino cellulose derivatives. The purpose of the study was the assessment of the biocompatibility of 6-deoxy-6-aminoethyleneamino cellulose (AEAC) with different degree of substitution (DS). HaCaT keratinocyte cell viability was analyzed by measuring the cellular ATP content. The antibacterial activity against Staphylococcus aureus and Klebsiella pneumoniae was examined by microplate laser nephelometry. Thus, the ratio of half-maximal lethal concentration (LC50) and half-maximal inhibitory concentration (IC50) was calculated and described as biocompatibility index. The study revealed that biocompatibility of AEAC depends on the DS. AEAC of low DS (0.3) showed the best biocompatibility.