The testis:an accessible Mesenchymal Stem Cells source

• 作者: Asma Amleh Myret Ghabriel
• 来源期刊: 现代肿瘤学研究进展(英文)
• 学科: 医学
• 关键词: TESTICULAR MESENCHYMAL STROMAL stem cells MSC SOURCES MSC isolation multilineage potential THERAPEUTIC application
• 年，卷（期）: 2018,（6）
• 页码范围: 5-17
• 页数: 13页
• 分类号: R32

摘要

Mesenchymal stem cells(MSCs)are adult stem cells that are predominantly found in bone marrow but also cord blood,peripheral blood,lungs,and adipose tissue.They are considered multipotent cells,which can differentiate to form multiple cells types—adipocytes,bone,cartilage,skin,and muscle.This potential elicits a great deal of attention because it appears to hold great promise regarding regenerative cell-based therapy to treat various diseases,including cancer.They are considered powerful allogeneic nonhematopoietic transplantation stem cells due to their low immunogenicity.Recently,several researchers have identified and isolated MSCs from primary human testes cultures.This review aimed to highlight the latest advances in MSC biological properties and characteristics studies,focusing on testicular mesenchymal stromal stem cells(tMSC),their differentiation capacity,and immunosuppressive properties—all of which have the potential to establish MSCs as powerful therapeutic agents for various diseases,including cancer.