Non-Obese Type 2 Diabetic Rat Models-GK Rat and SDT Rat

• 作者: Chikako Yoshida Masami Shinohara Phanthila Sirichaiyakul Rumpar Techasakulsin Suhattaya Furuta Taiichiro Kamiya Takahisa Yamada Takayuki Gotoh Takeshi Ohta Tomohiko Sasase
• 来源期刊: 动物科学期刊(英文)
• 学科: 医学
• 关键词: DIABETIC Model GK RAT SDT RAT TYPE 2 DIABETES
• 年，卷（期）: dwkxqkyw_2018,（4）
• 页码范围: 396-420
• 页数: 25页
• 分类号: R5

摘要

The number of diabetic patients has recently been increasing all over the world together with lifestyle changes including sedentary life and high-calorie diet intake, and as a result the increase in these suffering from diabetes mellitus has become a global issue. Diabetic animal models play a key role in bettering our understanding of the pathophysiology of diabetes and in developing new therapies for the disease. Diabetes is classified into two types, type 1 and type 2, and type 2 diabetes is chiefly caused by a depletion of insulin secretion in the pancreas and insulin resistance in peripheral tissues. The Goto-Kakizaki (GK) rat and the Spontaneously Diabetic Torii (SDT) rat are genetic non-obese type 2 diabetic models, and the both rats are considered to be suitable models for investigating the etiology of the depletion of insulin secretion and impaired glucose tolerance. In this review, we overviewed the outline of pathophysiological features in GK rats and SDT rats, including biological parameters and pharmacological responses.