异基因造血干细胞移植前后应用地西他滨治疗骨髓增生异常综合征转化的急性髓系白血病——1例治疗经验及文献复习

• 作者: 刘焕凤 刘耀 孔佩艳 张曦 张诚 蔺诗佳 许国发 邓天霞 陈婷 高力 高蕾
• 来源期刊: 临床血液学杂志
• 学科: 医学
• 关键词: FLT3-ITD阳性 急性髓系白血病 骨髓增生异常综合征 地西他滨 异基因造血干细胞移植 无关供者
• 年，卷（期）: 2018,（1）
• 所属期刊栏目: 病例报告
• 页码范围: 52-56
• 页数: 5页
• 分类号: R733.7
• 语种: 中文
• DOI: 10.13201/j.issn.1004-2806.2018.01.013

摘要

Acute myeloid leukemia (AML) transformed by myelodysplastic syndrome (MDS) has low complete remission,high risk of relapse,short survival time and poor prognosis.If the patients also with FLT3-ITD positive,the outcome will be worse,and the possibility of survival is very low,even after allogeneic hematopoietic stem cell transplantation (Allo-HSCT).In this paper a 44 year old female patient with FLT3-ITD+ AML-M5,transformed by MDS treated in our department were reported.The patient received chemotherapy with decitabine before and unrelated donor Allo-HSCT,and maintenance therapy of small dose of decitabine after HSCT.The early relapse after transplantation was successfully controlled,and the life of the patient had been over 2 years.