Study on the Mechanism of PERK Rgulating Radiosensitivity of Hepatocellular Carcinoma Cells

• 作者: Li Qiang Zheng Xiaogang
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报:英文版
• 学科: 医学
• 关键词: CARCINOMA PERK TP53
• 年，卷（期）: 2018,（1）
• 页码范围: 147-147
• 页数: 1页
• 分类号: R73

摘要

In addition to inducing apoptosis,necrosis,autophagy,and bystander effects,carbon ionizing radiation can also induce endoplasmic reticulum(ER)stress.As the most important trans-membrane sensor under ER stress,how PERK affects the radiosensitivity of cancer cells with different statuses of TP53,and ultimately determines the therapeutic effect against cancer,remain poorly understood.