Obesity and Protein Metabolism

• 作者: Emil Mukhamejanov Sara Erjanova
• 来源期刊: 药剂与药理学：英文版
• 学科: 医学
• 关键词: OBESITY protein METABOLISM FOOD model energy HOMEOSTASIS non-communicable disease
• 年，卷（期）: 2018,（11）
• 页码范围: 956-964
• 页数: 9页
• 分类号: R

摘要

A conceptual model of the interdependence between the metabolism of proteins,fats and carbohydrates taking into account the transport of the carbon skeleton and the stages of the relationship between the processes of formation and utilization of ATP(Adenosine Triphosphate)energy,which demonstrates the key role of protein metabolism and the maintenance of glucose homeostasis with different organism availability in energy was proposed.In supporting the processes of vital activity of the body,two periods should be analyzed.The first one is absorptive period,which is for providing rehabilitation processes,the expression of which is the“food pyramid”and the second one is postabsorptive period,which is for the energetic provision of physical and mental work,the expression of which is the“energy pyramid”.These pyramids differ in the ratio of macronutrients,and in their composition,which must be taken into account when developing the principles of human nutrition.Although obesity is seen as a simple discrepancy between the amount of intake of food calories and their utilization for physical activity,however,do not take into account the large energy expenditure on volatile processes,in particular,the process of protein synthesis.The process of protein synthesis depends on the availability in the substrate(amino acids),the intensity of mRNA expression(transcription)and the speed of reproduction(translation),so the violation at each of these stages will affect the energy balance and promote the development of obesity.Half of the protein mass is muscle,so it largely determines the homeostasis of glucose and the development of energy balance,which is presented in the form of an interdisciplinary model for the development of diabetes,obesity and cardiovascular diseases.In conclusion,technologies were proposed to support the process of protein synthesis and ways of preventing and treating obesity.