Obesity, which bring a great perplex to family and society, has significant contribution to the risk of diabetes, cardiovascular disease, and other comorbidities. In past four decades, the incidence of obesity has been on the alarming rise and so far about a third of the world's adults are affected by obesity. Due to the side effects and adverse reactions of drug treatment, obesity patients tend to select non-drug treatment. The present review summarizes the non-drug treatment of obesity in recent years, including acupuncture, exercise, surgery, lifestyle intervention and psychological guidance, to summarize their underlying mechanism and provide further guidance for clinical practitioners. Auricular acupuncture was proved to have the positively influence in Ghrelin, a novel obesity-related peptide hormone. Exercise could treat obesity by reducing the inflammatory factors associated with obesity. Furthermore, obesity surgery can not only reduce fat intake and nutrient absorption, but also inhibit the generation of Neuropeptide Y (NPY) by increasing the secretion of Peptide YY (PYY). Besides, breaking down psychological and behavioral barriers to lifestyle treatment of obesity will have a significant effect.