Associations between Body Mass Index and Breast Cancer Markers

• 作者: Ishita Saha Poonam Singh Rabindra Nath Das Sunit Kumar Medda
• 来源期刊: 肿瘤学研究(英文)
• 学科: 医学
• 关键词: ADIPONECTIN Breast cancer biomarkers BMI LEPTIN RESISTIN Joint mean variance modeling
• 年，卷（期）: 2020,（1）
• 页码范围: 1-7
• 页数: 7页
• 分类号: R58

摘要

Body mass index(BMI)and breast cancer biomarkers(BCBs)such as resistin,leptin adiponectin,monocyte chemoattractant protein-1(MCP-1)and homeostasis model assessment of insulin resistance(HOMA-IR)are highly associated with each other.The report has focused the inter-relationship between BMI and BCBs based on probabilistic modeling.It has been shown that mean BMI is directly associated with leptin(P<0.0001)and MCP-1(P=0.0002),while it is inversely associated with adiponectin(P=0.0003),HOMA-IR(P<0.0001),and it is higher for healthy women(P=0.0116)than breast cancer women.In addition,variance of BMI is inversely associated with resistin(P=0.1450).On the other hand,mean MCP-1 is directly associated with BMI(P<0.0001).Mean resistin is directly associated with the interaction effect of BMI and leptin(BMI^*Leptin)(P=0.0415),while its variance is directly associated with BMI(P=0.0942),and it is inversely associated with BMI*Adiponectin(P=0.1518).Leptin is directly associated with BMI(P<0.0001).Also adiponectin is inversely associated with BMI(P<0.0001),BMI*Leptin(P=0.1729),while it is directly associated with Age^*BMI(P=0.0017)and BMI^*Resistin(P=0.0615).It can be concluded that BMI and BCBs are strongly associated with each other.Care should be taken on BMI for breast cancer women.