Systematic Screening of Neonatal Sickle Cell Disease with HemoTypeSC<sup>TM</sup>Kit-Test: Case Study and Literature Review

• 作者: Emmanuel Tebandite Kasai Franç Jean Pierre Alworong’a Opara Justin Kadima Ntokumunda Nestor Ngbonda Dauly ois Boemer Roland Marini Djang’eing’a Salomon Batina Agasa
• 来源期刊: 血液病期刊(英文)
• 学科: 医学
• 关键词: SICKLE Cell Disease HEMOGLOBIN PHENOTYPE HemoTypeSC? NEONATES
• 年，卷（期）: 2020,（1）
• 页码范围: 12-21
• 页数: 10页
• 分类号: R73

摘要

emoTypeSC? test is a new cheap, faster, and appropriate screening method for neonatal diagnosis of sickle cell disease. The literature reports a few cases of its applicability. This study extends the cases study and reviews the available literature. The sample consisted of 99 subjects, including 87 newborns (36 girls and 51 boys;1.9 - 4.9 kg BW) sampled among 566 babies bone at six hospitals in Kisangani city (Democratic Republic of Congo) during March-April 2019;height infant-adolescents (<18 years);and four adults. Duplicate blood samples of 75 newborns, spotted on filter paper, were transferred to Liège in Belgium for LC-MS test confirmation. Of 99 subjects, 74.74% tested HbAA, 24.26% HbAS and 1% HbSS. The prevalence of HbAS compared to the HbAA phenotype was 15/60 (20%) by HemoTypeSC? and 14/61 (18.7%) by LC-MS. The concordance between the two methods was 98.3% or a discordance of 1.7%. The findings support the validity of the HemoTypeSC? test as a sensitive, specific point of care test, cheap and reliable for poor African populations.