<i>In Situ</i>Characterization of Lopinavir by ATR-FTIR Biospectroscopy

• 作者: Alireza Heidari
• 来源期刊: 计算化学(英文)
• 学科: 工学
• 关键词: ATR-FTIR Biospectroscopy Simulation LOPINAVIR Breakdown Coronavirus Disease-2019 COVID-19 Infection Protective and Therapeutic Effect Potent Drug
• 年，卷（期）: 2020,（3）
• 页码范围: 27-42
• 页数: 16页
• 分类号: TN2

摘要

<p> Lopinavir is an antiretroviral of the protease inhibitor class (Figure 1 <span style="display:none;" id="__kindeditor_bookmark_end_3__"></span>and Figure 2). It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir). In the current research, the stimulated ATR-FTIR biospectroscopy of liquid sample of Lopinavir was investigated. The stimulated ATR-FTIR diffractions emitted through focusing the second harmonic laser beam Nd:YAG into the sample were recorded by Echelle spectrometer and ICCD detector. Increasing the energy of laser beam from 2.6 (mJ) to 16 (mJ) led to increase in stimulated ATR-FTIR signal but after breakdown threshold of liquid sample, further increasing energy led to the decrease in stimulating ATR-FTIR signals and for energies higher than 20 (mJ), they were disappeared. </p>