Lung cancer screening, what has changed after the latest evidence?

• 作者: Elisabeth Martinez-Tellez Felipe Counago Juan Carlos Trujillo-Reyes Luis Seijo
• 来源期刊: 世界放射学杂志:英文版(电子版)
• 学科: 医学
• 关键词: Lung cancer EPIDEMIOLOGY Lung cancer screening Low dose chest computed tomography scan Primary prevention Molecular biomarkers
• 年，卷（期）: 2020,（7）
• 页码范围: 130-136
• 页数: 7页
• 分类号: R73

摘要

Lung cancer(LC)is still one of the most frequent cancers with a high related mortality.Their prognosis is directly proportional to the stage at the time of diagnosis.Seventy percent are currently diagnosed in advanced or locally advanced stage(higher than stage III),making a cure unlikely for the majority of patients.Developments in LC treatment are significant however they do not seem to be enough to reverse the current situation,at least,in a short period of time.Despite recent advances in treatment,primary prevention and early diagnosis appear to be the key to reduce the incidence and mortality of this disease.Many countries have developed LC screening programs based on the results of clinical trials published in recent years.The aim of this paper is to review the latest results of the NEderlands Leuvens Longkanker Screenings Onderzoek and compare them with the findings of the National Lung Screening Trial.We address the question whether it is necessary to continue discussing the evidence regarding LC screening.In both trials,there is a clear impact on LC mortality but,with a modest reduction in over all mortality.Undoubtedly,the benefit of screening can be expected to grow as low-dose computed tomographys are performed over longer periods of time.