Role of non-coding RNAs in pathogenesis of gastrointestinal stromal tumors

• 作者: Georgios C Zografos Ioannis K Stefanou Konstantinos G Toutouzas Maria Gazouli
• 来源期刊: 世界荟萃分析杂志
• 学科: 医学
• 关键词: Gastrointestinal stromal tumors Non-coding RNA MICRORNA TRANSCRIPTOMICS BIOMARKER Long non-coding RNAs
• 年，卷（期）: 2020,（3）
• 页码范围: 233-244
• 页数: 12页
• 分类号: R73

摘要

Gastrointestinal stromal tumors(GISTs)are considered the model solid malignancies of targeted therapy after the discovery of imatinib effectiveness against their tyrosine kinase inhibitors.Non-coding RNAs are molecules with no protein coding capacity that play crucial role to several biological steps of normal cell proliferation and differentiation.When the expression of these molecules found to be altered it seems that they affect the process of carcinogenesis in multiple ways,such as proliferation,apoptosis,differentiation,metastasis,and drug resistance.This review aims to provide an overview of the latest research papers and summarize the current evidence about the role of non-coding RNAs in pathogenesis of GISTs,including their potential clinical applications.