The antipyretic effects of Chai Ge fever relief oral liquid

• 作者: Sai-Wei Lu Shan-Shan Guo Xiao-Lan Cui Ya-Xin Wang Ying-Jie Gao
• 来源期刊: 药物联合治疗
• 学科: 医学
• 关键词: Chai Ge fever relief oral liquid YEAST ENDOTOXIN Parainfluenza virus Antipyretic effect Fever model
• 年，卷（期）: 2020,（3）
• 页码范围: 104-113
• 页数: 10页
• 分类号: R73

摘要

Backgroud:To verify the antipyretic effect and mechanism of Chai Ge fever relief oral liquid,and to provide evidence for the clinical application of Chai Ge fever relief oral liquid.Methods:By designing three groups of experimental models of yeast-induced rat fever model,endotoxin-induced rabbit fever model,and para-influenza virus-induced rabbit fever model,the antipyretic effect and mechanism of Chai Ge fever relief oral liquid were studied by measuring body temperature before and after treatment and the expressions of protein kinase A(PKA),protein kinase C,arginine vasopressin(AVP),prostaglandin E2 and cyclic adenosine monophosphate(cAMP)in hypothalamus after administration.Results:In the yeast-induced fever model of rats,the body temperature and PKA expression levels in different dose groups of Chai Ge fever relief oral liquid were significantly different from those of the model group 1–3 h after treatment.In the rabbit fever model induced by endotoxin,different dosage groups of Chai Ge fever relief oral liquid have obvious antipyretic effect on 1–3 h after the model is established,and can significantly reduce the expression of AVP and cAMP in hypothalamus.In the para-influenza virus-induced rabbit fever model,each dose group of Chai Ge fever relief oral liquid has obvious antipyretic effect on 1–2 h after the model is established.Conclusion:Chai Ge fever relief oral liquid has good antipyretic effect on fever models induced by yeast,endotoxin and parainfluenza by regulating the expression of PKA,AVP,and cAMP.