Impact of polyherbal formulations MEF-4 and MEF-8 on high fat diet induced obesity in SD rats

• 作者: Debashish Paramanick Shikha Yadav Vijay Kumar Singh Vikash Sharma
• 来源期刊: 亚洲传统医药
• 学科: 医学
• 关键词: POLYHEDRAL HYPERLIPIDEMIA lipid profile OBESITY
• 年，卷（期）: 2020,（4）
• 页码范围: 164-171
• 页数: 8页
• 分类号: R58

摘要

As a traditional healing system of India,herbal medicines have been used as therapeutics over a long period of time.In the present study,polyherbal formulations MEF-4 and MEF-8 from two pharmacologically important plants,Camelia Sinensis(CS)and Citrus Aurantium(CA),were studied in vivofor their potential in reducing obesity and hyperlipidemia.These twoformulations are different from each other in the manner that they contain two different polymers and that MEF-4 was prepared through cold extraction of CS and Cl and MEF-8 was prepared through hot extraction method.Hyperlidemia leads to many complications like hypertension,stroke and heart attack.It also creates complications to the patients suffering from chronic disorders like diabetes and stress.The aim of the present investigation is to assess the effect of these twoformulations on the possibility of reducing obesity.The rodents enlisted in hyperlipidemia had taken a high-fat diet for about 14 d.The hyperlipidemic rodents of 250 g were taken in the study,treated with standard eating regimen and high-fat eating regimen orally for 30 d.After treatment for 30 d,blood tests from the MEF-4/MEF-8/standard/vehicle were gathered and an impact on body weight,hematology and lipid profile was investigated.Statistical analysis showed there was a significant increase in cholesterol(CHL),low density lipoprotein(LDL),triglyceride(TG),phospholipids(PHL)change in the body weight of group Ⅰ(HFD)and Ⅱ(STD)as compared to group Ⅲ(MEF-4)and group IV(MEF-8).The decline in triglyceride(P<0.01)was also noted for MEF-8 when compared to control and standard.