Restless legs syndrome following the use of ziprasidone: a case report

• 作者: Brian Isaacson Cuizhen Zhu Daomin Zhu Hui Zhou Qingwei Li Ran Bi Yezhe Lin Yuliang Hu
• 来源期刊: 综合精神医学(英文)
• 学科: 医学
• 关键词: doses DOPAMINE MEDICATION
• 年，卷（期）: zhjsyxyw,（2）
• 页码范围: 111-113
• 页数: 3页
• 分类号: R97

摘要

Restless legs syndrome(RLS)is a common sleep-related movement disorder characterised by an uncomfortable urge to move the legs that occurs during periods of inactivity.Although there have been many case reports on antipsychotic-induced RLS,ziprasidone has never been reported as a cause of RLS.We present a case of a female patient with schizophrenia who presented with symptoms of RLS following the administration of high doses of ziprasidone added to quetiapine and valproate.The patient’s symptoms of RLS occurred following the administration and titration of ziprasidone to 160 mg,and were relieved upon reducing the dose to 120 mg/day.Other potential causative medications and differential diagnoses that could have caused similar symptoms were excluded.Clinicians should be aware of the potential for ziprasidone-induced RLS.Dopamine and serotonin interaction could be the mechanism underlying ziprasidone-induced RLS.