Level of Cardiac Biomarkers in Immediate Post-Operative Period after Off-Pump CABG and Its Comparison with On-Pump CABG: A Prospective Analytical Study

• 作者: Ashis Halder Pares Bandyopadhyay Sayar Kumar Munshi
• 来源期刊: 心血管外科国际期刊(英文)
• 学科: 医学
• 关键词: Coronary Artery Bypass Grafting (CABG) Perioperative Period Myocardial Damage Cardiopulmonary Bypass Cardiac Biomarkers
• 年，卷（期）: 2020,（10）
• 页码范围: 200-211
• 页数: 12页
• 分类号: R65

摘要

<strong>Background</strong><b><span style="font-size:12px;font-family:Verdana;">:</span></b><span style="font-size:10.0pt;font-family:;" "=""><span style="font-family:Verdana;font-size:12px;"> Coronary artery bypass grafting (CABG) is an important modality of treatment for ischemic heart disease. Both off-pump and on-pump CABG have direct effect on the level cardiac biomarkers in the perioperative period. The use of cardiopulmonary bypass (CPB) and aortic cross-clamping may cause additive myocardial damage leading to further elevation of blood markers. The present study is aimed at measuring and comparing the cardiac biomarker levels in immediate post-operative period after on-pump CABG (ONCAB) and off-pump CABG (OPCAB). </span><b><span style="font-family:Verdana;font-size:12px;">Methods</span></b></span><b><span style="font-size:12px;font-family:Verdana;">:</span></b><span style="font-size:12px;font-family:Verdana;"> All the patients who underwent CABG from January 2015 to June 2016 on elective or emergency basis at Nilratan Sircar Medical College & Hospital have been included in the study. Total 106 patients were operated for CABG of which 75 patients were operated for OPCAB and 31 patients were operated for ONCAB.</span><span style="font-size:10.0pt;font-family:;" "=""> </span><span style="font-size:10.0pt;font-family:;" "=""><span style="font-family:Verdana;font-size:12px;">For the comparison of data the blood markers Troponin-T (Trop-T) and Creatine Kinase-MB (CK-MB) are measured during anesthesia before surgery, </span><span style="font-family:Verdana;font-size:12px;">post-operatively after 1</span></span><span style="font-size:10.0pt;font-family:;" "=""> </span><span style="font-size:12px;font-family:Verdana;">hour, post-operatively after 4</span><span style="font-size:10.0pt;font-family:;" "=""> </span><span style="font-size:12px;font-family:Verdana;">hours and post-operatively</span><span style="font-size:12px;font-family:Verdana;"> after 20</span><span style="font-size:10.0pt;font-family:;" "=""> </span