Correlation between Carotid Plaque Characteristics without Operative Indication and Ischemic Stroke

• 作者: Qian Wang Sibo Liu Anni Long Jingzhe Liu Xiaowei Zhang Lei Li
• 来源期刊: 中国生物医学工程学报（英文版）
• 年，卷（期）: 2020,（2）
• 所属期刊栏目: Research papers
• 页码范围: 17-24
• 页数: 8页
• 语种: 英文

摘要

Objective To access the correlations between characteristics of carotid plaque in MRI and ischemic stroke in patients with ≤50％ carotid artery stenosis. Methods A total of 43 patients with≤50％ carotid artery stenosis were selected for ul-trasound from September 2014 to February 2016. A further test using magnetic resonance (MR) black blood imaging exam-ination were carried out to distinguish the anatomy of the vessel as well the composition of the atherosclerotic plaque with re-markable details. The relationship between carotid plaque characteristics in MRI and other risk factors of patients with is-chemic stroke was analyzed by univariate and multivariate analysis. Results The mean follow-up time was 11. 8 months. During the follow-up period, 4 of the 43 individuals experienced an ipsilateral ischemic stroke. Kaplan-Meier survival a-nalysis showed the mean ischemic stroke free survival of patients with coronary heart disease ( CHD) was significantly shor-ter than that in patients without CHD, which were 12. 1 months and 18. 7 months respectively (P=0. 029). The mean is-chemic stroke free survival of patients with intra-plaque hemorrhage ( IPH) was significantly shorter than that in patients without IPH, which were 14. 3 months and 18. 6 months respectively (P=0. 001). COX regression analysis showed that coronary heart disease (HR=27.4;95％ CI, 1. 6-464. 3; P=0. 022) and IPH (HR=18. 2; 95％ CI, 2. 7-123. 3;P=0. 003) were independent risk factors for ischemic stroke. Conclusion For patients with carotid artery stenosis≤50％, IPH of carotid plaques and CHD are independent risk factors for ischemic stroke.