Assessment of disease activity in inflammatory bowel diseases:Non-invasive biomarkers and endoscopic scores

• 作者: Bruno Lima Rodrigues Cristiane Kibune Nagasako Joao Jose Fagundes Marcia Carolina Mazzaro Maria de Lourdes SetsukoAyrizono Raquel Franco Leal
• 来源期刊: 世界胃肠内镜杂志:英文版(电子版)
• 学科: 医学
• 关键词: Inflammatory bowel diseases Biomarkers Endoscopic scores Crohn's disease Ulcerative colitis INFLAMMATION
• 年，卷（期）: 2020,（12）
• 页码范围: 504-520
• 页数: 17页
• 分类号: R57

摘要

Inflammatory bowel diseases(IBD)comprise two major forms:Crohn’s disease and ulcerative colitis.The diagnosis of IBD is based on clinical symptoms combined with results found in endoscopic and radiological examinations.In addition,the discovery of biomarkers has significantly improved the diagnosis and management of IBD.Several potential genetic,serological,fecal,microbial,histological and immunological biomarkers have been proposed for IBD,and they have been evaluated for clinical routine and clinical trials.Ileocolonoscopy,especially with biopsy collection,has been considered the standard method to diagnose IBD and to assess clinical activity of the disease,but it is limited to the colon and terminal ileum and is considered invasive.For this reason,non-invasive biomarkers are necessary for this type of chronic inflammatory disease,which affects mostly young individuals,as they are expected to have a long follow-up.