Goodpasture syndrome and hemorrhage after renal biopsy: A case report

• 作者: Chun-Di Li Ping Zeng Shao-Dong Luan Shu-Yuan Zhang Wei-Long Li Xi Wang Xing Wei Ying-Wei Zhang Zi-Gan Xu
• 来源期刊: 世界临床病例杂志
• 学科: 医学
• 关键词: Goodpasture DISEASE Anti-glomerular BASEMENT MEMBRANE DISEASE RENAL BIOPSY HEMORRHAGE Glomerular BASEMENT MEMBRANE Case report
• 年，卷（期）: 2020,（2）
• 页码范围: 404-409
• 页数: 6页
• 分类号: R69

摘要

BACKGROUND Goodpasture syndrome(GS) is a rare disease, the morbidity of which is estimated to be 0.5-0.8 per million per year. Hemorrhage is the most serious complication in renal biopsy. Despite the fact that both GS and hemorrhage after renal biopsy are rare, it has not been reported that they are likely to occur in the same patient.CASE SUMMARY A 30-year-old man with diffuse pulmonary hemorrhage and rapid progressive renal function caused by anti-glomerular basement membrane disease presented atypical symptoms without hemoptysis, accompanied by life-threatening hypoxemia. Plasmapheresis was performed, and glucocorticoids and cyclophosphamide were administered. The patient started to show signs of improvement. Percutaneous renal biopsy is an appropriate diagnostic measure that is commonly safe, but this patient experienced hemorrhage after operation,thus necessitating embolization of the renal artery to stop the bleeding. The patient’s condition was improved, and the serum anti-glomerular basement membrane antibody level was 106 AU/m L(normal range: < 24 AU/m L) and slowly decreased. His discharge medications were oral daily prednisone(30 mg)and continued maintenance hemodialysis.CONCLUSION GS is a rare organ-specific autoimmune disease that is invariably ubiquitous in the lung and kidney areas. Renal biopsy is the appropriate procedure for the treatment of GS disease, although it is an invasive measure.