Metabonomic analysis of plasma biochemical changes in pyrexia rats after treatment with Gegenqinlian decoction, aspirin and itraconazole by UHPLC-FT-ICR-MS

• 作者: Ruiyun Li Ting Liu Yue Cui Yunli Zhao Zhiguo Yu
• 来源期刊: 药物分析学报（英文）
• 年，卷（期）: 2020,（6）
• 所属期刊栏目: Original Articles
• 页码范围: 581-587
• 页数: 7页
• 语种: 英文

摘要

A metabonomic approach involving an ultrahigh-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS) was used to investi-gate the changes in the endogenous metabolites in the plasma of rats with yeast-induced pyrexia treated with Gegenqinlian decoction (GQLD), aspirin and itraconazole. The differences in the small molecule profiles of treatment using traditional Chinese medicine, etiological treatment and symptomatic treat-ment were elucidated. Thirty-six plasma metabolites were identified or putatively identified, and the effects of the three medicines on the thirty-six metabolites were studied. Their metabolic pathways indicated that GQLD, aspirin and itraconazole ameliorated the rats with yeast-induced pyrexia pre-dominantly by regulating the metabolisms of phospholipid, sphingolipid, fatty acid oxidation, fatty acid amides, amino acid and glycerolipid in vivo. The pharmacodynamics and metabonomic results showed that the three medicines exhibited the therapeutic effects on pyrexia by regulating the perturbations of multiple metabolisms. The study provided a scientific basis for an in-depth understanding of the ther-apeutic effects of GQLD, aspirin and itraconazole on rats with yeast-induced pyrexia.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	Ting Liu		1	0	0.0	0.0
2	Ruiyun Li		1	0	0.0	0.0
3	Yue Cui		1	0	0.0	0.0
4	Zhiguo Yu		1	0	0.0	0.0
5	Yunli Zhao		1	0	0.0	0.0