Quorum sensing refers to the phenomenon that bacteria sense signal molecules in the environment and regulate a series of genes.At present,the known quorum sensing systems in Staphylococcus aureus are the Agr system and the LuxS/AI-2 system.They will be activated when the bacterial concentration is equal to or greater than 107/ml,and by regulating the corresponding genes,bacteria can indirectly or directly regulate the production and degradation of biofilms,the secretion of bacterial toxins and the growth of bacteria.In this paper,we summarized the research progress of quorum sensing in S.aureus by consulting relevant literatures at home and abroad on quorum sensing in S.aureus,so as to find a new direction for the future research on S.aureus.