Combined transarterial chemoembolization and stereotactic body radiation therapy as a bridge therapy to liver transplant for hepatocellular carcinoma

• 作者: Bui Quang Bieu Nguyen Dinh Chau Nguyen Xuan Kien Le Van Thanh Vu Van Quang Thai Doan Ky Nguyen Tien Thinh Mai Hong Bang
• 来源期刊: 肝癌研究（英文版）
• 年，卷（期）: 2020,（8）
• 所属期刊栏目: Case Report
• 页码范围: 36-45
• 页数: 10页
• 语种: 英文
• DOI: 10.20517/2394-5079.2020.39

摘要

Liver transplant (LT) is the curative treatment for patients with hepatocellular carcinoma (HCC). Bridge therapies are local treatments given to patients on the LT waitlist, to prevent tumor progression and to reduce the dropout rate. Case presentation: We reported a 40-year-old man diagnosed with Barcenola-Clinic Liver Cancer BCLC intermediate stage HCC and Child-Pugh A5 hepatitis B virus cirrhosis who underwent combined bridge therapies to LT. Firstly, the patient received transarterial chemoembolization (TACE) for two times and showed a partial response. Then he underwent stereotactic body radiation therapy (SBRT) with a total dose of 45 Gy in 3 fractions. Three months later, the tumor size and serum protein induced by Vitamin K absence or antagonists-II, alpha fetoprotein levels decreased gradually. In June 2019 a suitable donor was found and his LT was successfully performed. Conclusion: We propose that a combination of TACE and SBRT was feasible as bridge therapy for HCC patients on the LT waitlist.